The impact of osteoarthritis in elderly population in our society is steadily increasing, because of the continued rise in the mean age of the population. With treatment being variably effective and difficult, it still remains a challenging problem worldwide for all orthopedic surgeons. The regeneration capacity of cartilage is limited because of its isolation from systemic regulation and lack of vessels and nerve supply. Unlike, most tissues none of the inflammatory processes is available for its repair, and chondrocytes cannot migrate from an intact healthy site to the site of osteoarthritis. OA has a major impact on functioning of the knee and independence and ranks among the top ten causes of disability worldwide.