Back ground and aims:– Spinal anesthesia has lower complication than general anesthesia in both mother and foetus, In which hypotension is major complication. This study was designed to evaluate and compare with prophylactic use of phenylephrine and ephedrine to reduce hypotension in caesarean section.

Method: – Eighty patients of the American society of anesthesiologists physical status grade I or II , scheduled for caesarean  section under spinal anesthesia, were randomly allocated into two group A and B.  Group A– received : 4 mg of phenylephrine  and diluted upto 1.5 ml NS and group B – received : 1.5 ml of ephedrine 45 mg.  Ten minute before of spinal anesthesia, The intramuscular injection of study medication was given into the right vastus lateralis muscle, data were analyzed with chi–square test for categorical variables in dependent sample. T– test and mann whitney U test for continuous variables was applied for analysis of the study.

Result :–  In our study, incidence of hypotension was significant less in phenylephrine (10%) as compare of ephedrine group ( 27.5%) and incidence of nausea, vomiting was less in phenylephrine group as compared to ephedrine group. It was statistically significant (P<0.05).

Conclusion :–  Phenylephrine was found to be better than ephedrine for prevention of spinal anaesthesia induced hypotension, nausea and vomiting.