IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-2-14076 Original Research Paper Effect of Blood 25–hydroxy vitamin D [25(OH)] levels on Prediabetes patients : A Meta–analysis of Randomised Control Trials Choudhary Dr. Poorvi Gupta Dr. February 2018 7 2 01 02 ABSTRACT

 

Background:  Emerging evidence suggests that vitamin D may play a role in the development of diabetes. This metaanalysis was done to evaluate effect of Vitamin D on blood glucose level among prediabetes patients. Objective: To evaluate the effect of vitamin D on glycaemic control in Prediabetes in different RCT performed.  Methods: A literature search was conducted of MEDLINE, the Cochrane Library, (CINAHL), Scopus, Web of Science through the reference lists of relevant articles until end of November 2017. Studies were included if they were RCT of vitamin D or vitamin D analogues in prediabetes. Treatment effect was estimated according to mean difference in the changes 2h oral glucose tolerance test plasma glucose, fasting plasma glucose and HbA1C between vitamin D and control groups. Results: A total of 10 randomized controlled trials were included. Vitamin D did not significantly improve 2h oral glucose tolerance test plasma glucose: the mean differences were 0.06 (95% CI 0.36 to 0.24) and 0.23 mmol/l (95% CI 0.65 to 0.19), respectively. Conclusions: Low beneficial effect of Vitamin D improving the blood glucose levels in prediabetes was identified.