Summary – Mucormycosis was considered universally fatal until isolation of Amphotericin B in 1961,  the 1^st survivor  reported. Having a prevalence rate of around 8% – 13% of all fungal infections, these cause fatal infections in immune–compromised individuals Being a diabetic capital, most of the cases presenting at advanced stage commonly rhinocerebral or rhino–orbito–cerebral. Here, we present a case series of mucormycosis, their clinical management, and course of the disease with literature review and suggest an easy protocol.

Objective – Devise a treatment protocol to help in early diagnosis of mucormycosis

Methods – Prospective, cross–sectional, interventional study. Duration – 6 months. N=13 consecutive mucormycosis cases. Demographic parameters, co–morbidities, clinical presentation, stage at presentation, diagnostic nasal endoscopy findings, radio–imaging, , and Quality–Of–Life (QOL) questionnaire data were recorded and compared. Statistical analyses were done.

Results – Mucorales were commonly isolated from diabetic individuals.. High mortality rate. Poor QOL.