Background: Our understanding of Systemic Lupus Erythematosus (SLE) has been evolved very significantly over the period of last few decades. The hematological abnormalities though more commonly seen are not properly evaluated or estimated and are not given enough representation . In some of these cases presenting with Anaemia, Thrombocytopenia, Pancytopenia or Thrombotic episodes, especially so in young females, the diagnosis may be delayed or initially missed if the index of suspicion is low or if there is improper and inadequate follow up. Thus keeping this in mind this study as be carried out. Aim and Objectives :(1) To study Haematological manifestations of SLE and (2) To study its correlation with the disease severity. Materials and Methods: This study is an Observational Cross Sectional Study done in Assam Medical College for a period of one year. All cases who fulfilled the ACR criteria 1997 who came to Rheumatology opd and those who admitted in Medicine ward taken up for the study. Results: Totally 106 patients were taken up for the study. The most common constitutional symptom was Fatigue which present among 57 (53.7%). Raynaud ’s phenomenon was present among 15(14.15%) patients. Anaemia was present in 99 patients (93%) of the study group with most common type being Anaemia of chronic disease. Neutropenia was present among 8 (7.5%), Thrombocytopenia among 8(7.55%) in the study group. Severity of anaemia and Serum Ferritin Level were in correlation with the Disease severity (SLEDAI). Conclusion: Haematological Manifestations is one of the most common manifestation presents very early in the disease process and in many cases as the only presentation. This Study demonstrated similarities with most of other studies, revelling at the same time much Higher incidence of Haemotological manifestations compared to other studies.