Objective: To study various histopathological lesions in resected appendices with special reference to unusual pathologies.

Methods: This is a retrospective five year study of 1016 appendectomy specimens. Detailed gross examination of appendectomy specimens was done, representative bits were taken and processed as per standard protocol for H & E stain. The pertinent clinical data and histopathological diagnoses were analysed.

Results: The frequency of appendectomy specimens contributed to 10.06% in all surgical specimens. Males outnumbered the females (61.42%). Maximum number of cases were found in the age group of 11–20 years (32.68%). The bulk was formed by acute appendicitis (96.65%) with perforation in 5.19% cases. Unusual pathology ranging from granulomatous inflammation to malignancy was observed in 0.69% of cases.

Conclusion: Present study emphasizes histopathological examination in every single resected specimen of appendix, as histopathology is the gold standard confirming the diagnosis