IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-2-14134 Original Research Paper CONCURRENT CHEMORADIATION WITH SEQUENTIAL VERSUS INTERDIGITATED BRACHYTHERAPY FOR LOCALLY ADVANCED CARCINOMA CERVIX – AN OPEN LABEL RANDOMISED CLINICAL TRIAL Abhishek Basu Dr. Dr. Avik Maji Dr. Prof. Dr. Swapan Kr Sikdar Dr. February 2018 7 2 01 02 ABSTRACT

 

Background

This is a prospective study to evaluate the effects of treatment duration shortening by means of Interdigitated brachytherapy comparing with conventional external beam radiotherapy followed by brachytherapy.

Material & Methods

  In study arm, The high dose rate intracavitary brachytherapy  using Ir192 was interdigitated from the 3rd week of EBRT, was given in 3fractions.  In control arm, brachy started after 1week of EBRT.

      During treatment patients were reviewed weekly. After treatment completion, patients were reviewed at six weeks, then three–monthly thereafter.

       Results

This study  has achieved good response (96 % CR post Brachytherapy at 3 month) and local control rate (95% v/s 68% at end of follow up),which was better than sequential arm , with slightly better DFS but No OS difference.

Conclusion

Interdigitated  Brachytherapy can be delivered as a standard mode of treatment in cancer cervix. Continuing this study for prolonged period and recruiting more patients will help in arriving at conclusive results