Hemophilia is an X linked disorder which is caused by a deficiency of Factor VIII and Factor IX. The worldwide prevalence of this disorder is approximately half a million. Haemophilic families are always under emotional and financial stress, as the treatment is very expensive. Genetic studies of Hemophilia are an essential for the management of this disorder. Carrier detection and genetic counselling in affected families can significantly help in reducing the incidence. This review article summarizes genetic aspects of Hemophilia with components of genetic evaluation and management of Hemophilia.