Purpose: The incidence of hematological malignancies are increasing. There is sparse data regarding epidemiology of this subset of disease from Himalayan foothill in India. Extrapolation from other geographical terrain is not helpful as environment, ethnicity and health habits are different in this region.

Material and Method: A retrospective analysis was done for all proven hematological malignancies enlisted at Cancer Research Institute, Dehradun during 2012–2015. Data was analyzed for disease spectrum, demographic profile and age of presentation.

Results: Study noted 597 confirmed hematological malignancies during study period. Male predominance was noted in all subset. Non Hodgkin lymphoma was most commonly noted adult hematological malignancy (26.9%) while leukemias were commonest in pediatric age group. Unusually high proportion of multiple myeloma (24.4%) was noted as well.

Conclusion: Study depicted unique and interesting pattern of disease epidemiology in this geographical area. A more detailed epidemiological exercise should be carried out to identify the reason of such difference.