Aim:

          To determine Correlation of eGFR and TKV with HbA1c and micro–albuminuria in newly diagnosed DM type 2 and other variables of these parameters known to be associated with diabetic nephropathy.

Methods:

            This was an hospital based observational case study. Total 66 newly diagnosed DM type 2 cases were included in this study. A detailed history and physical examination were recorded. The following laboratory investigations were done – fasting and postprandial blood sugar and glycosylated haemoglobin. Micro–albuminuria was tested in urine using clinitek microalbumin test strips. GFR was estimated by the creatinine clearance and TKV was determined by ultrasonography.

Result:

           In this study a significant correlation was found between eGFR with micro–albuminuria, fasting blood sugar (p<0.001), post prandial blood sugar ( p<0.001) and glycosylated Hb ( p= .03) but non– significant correlation was found between eGFR with SBP ( p=0.57) , DBP( p=0.77) and TKV ( p= 0.08). Also non– significant correlation was found between TKV with micro–albuminuria, SBP (p=.16), DBP (p=.55), FBS (p=.06), PPBS (p=.42) andHbA1C (p=.99). 

Conclusion:

             We observed a significant correlation between eGFR with micro–albuminuria, fasting blood sugar, post prandial blood sugar and glycosylated Hb but non– significant correlation was found between eGFR with SBP, DBP and TKV but total kidney volume did not have any significant correlation with hypertension (SBP and DBP) and glycaemic control (FBS, PPBS and HbA1C) in newly diagnosed type 2 diabetic case. Hence concluded that early renal changes had correlation with the risk factors for diabetic renal disease and proper control of   parameters can bring about significant reduction in development of diabetic nephropathy.