Background & Objective: Alteration in thyroid profile is associated with change in basal metabolic rate of every organ. Thus, we aimed to assess and compare the effect of conventional antiepileptic drug, valproate and newer antiepileptic drugs, levetiracetam and oxcarbazepine mono therapy on serum thyroid profile in adult epileptic patients.

Methods: Patients on stable dose of valproate (n=14), levetiracetam (n=14), or oxcarbazepine (n=14) mono therapy for at least six months, and age and gender matched healthy controls (n=14) were included and analyzed for T₃, T₄, TSH.

Results: With oxcarbazepine, significantly low T₃ (P=0.0138), T₄ levels (P=0.0021) and no significant difference in TSH (P=0.8566) was observed compared to control. No significant difference in thyroid profile was observed compared to control in other groups and when newer AEDs were compared to valproate.

Conclusion: Thus, patients on oxcarbazepine may require monitoring of thyroid profile. Advanced long term studies are warranted to confirm these results.