Background: The aerobic bacterial profile and antibiotic sensitivity pattern of pyogenic infection is very important in view of increasing antimicrobial drug resistance, which renders the treatment of such infections very difficult. Objective: The aim of the study was to evaluate the bacterial profile and antibiogram of pus isolates in this part of country. Materials and Methods: Pus samples of 240 patients were evaluated for identification of aerobic bacteria by standard methods and antibiotic sensitivity testing was done by Kirby Bauer method. Results: Out of 240 pus samples, 143 samples (59.58%) showed growth of organisms. Out of 143 positive samples, 17 samples had growth of two organisms. So, total of 160 isolates obtained from 143 positive samples. Escherichia coli was the most common organism (23.1%) followed by Klebsiella pneumoniae (16.9%), Staphylococcus aureus (16.2%), Pseudomonas aeruginosa (13.1%), Acinetobacter baumannii (8.1%) among others. Among gram positive bacteria, Staphylococcus aureus was very sensitive to most of the antibiotics. On the other hand, gram negative bacteria were found to be very resistant specially Acinetobacter baumannii and  Klebsiella pneumoniae to most of the antibiotics. Conclusion: Changing pattern of antimicrobial sensitivity is a matter of concern in treating such pyogenic infections. Judicious use of antibiotics will limit the emergence of drug resistance in these organisms.