Background: Menopause is the natural process of ageing during which a woman passes from reproductive to non reproductive phase with cessation of cyclic ovarian functions as manifested by cyclic menstruation.  Aim The aim of this study was to assess circulating levels of gonadotropins like luteinizing hormone, follicle–stimulating hormone and prolactin as representative of pituitary hormones in postmenopausal women in comparison to premenopausal women from tertiary care hospitals of Punjab. Material and Methods: 40 premenopausal women and 40 postmenopausal women were included in the study. Fasting blood samples were collected for the assessment of luteinizing hormone, follicle–stimulating hormone and prolactin levels in both premenopausal and postmenopausal women.  Results: A significant increased was recorded in serum luteinizing hormone, follicle–stimulating hormone and prolactin  levels in postmenopausal women in comparison to premenopausal women

Conclusion: A significant increase in luteinizing hormone, follicle–stimulating hormone and prolactin levels in postmenopausal women suggested that we should evaluate thyroid functions along with hormonal evaluation to prevent further complications in postmenopausal women.