Background: Smoking is one factor which can alter the blood cell parameters. The aim of this study was to compare the levels of  blood cell parameters in smokers  as compared to healthy controls.

Materials and methods: Totally 50 patients between the age group 25 – 65 years were recruited for the present study. They were grouped as group I – healthy subjects,  and  group II – subjects who smoke. A single examiner collected the necessary periodontal recordings. Five millilitres of venous blood was collected from all the subjects and submitted for haematological analyses.

Results: Significant lower levels of rbc count attributed  to folic acid and vitamin B12 levels  in smokers. ESR was higher in smokers as compared to healthy individuals.

Conclusion: The result of the present study signifies that  smoking has an impact on  blood cells parameters.