Background : Depression is a common psychiatric illness affecting all age groups with high life time prevalence. Psychiatry has started searching for a biological basis with recent advances in functional  imaging techniques, like Single Photon Emission Computed Tomography to identify changes in cerebral perfusion associated with psychiatric illness Aim and objectives: To study cerebral perfusion changes in Recurrent Depressive Disorder subjects in different locations of brain using SPECT scan during depressive episode and comparing with normal subjects Material and Methods: Cross sectional, comparative and observational study at a tertiary care center with institutional ethics committee approval Results:. Significant difference in perfusion was noted only in left temporal region (p value < 0.03) in depression population when compared to control population Conclusion : Brain perfusion changes were observed in multiple brain regions, but significant only in Left Temporal region showing that perfusion pattern of brain has an association with depressive episode