IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-3-14394 Original Research Paper Effect of Risperidone and Clozapine on Executive Functions in First Episode Schizophrenia Ajeet Sidana Dr. Dr.Sukhtej Sahni Dr. March 2018 7 3 01 02 ABSTRACT


Aims: To compare the effect of risperidone and cloazpine on executive functioning in treatment naïve first episode schizophrenia. Methods: A total of 55 treatment naïve first episode patients of schizophrenia as per ICD–10 criteria, were enrolled for the study. Baseline assessment for executive functioning was carried out with TMT– A & B. Clozapine and risperidone were used in the range of 200–600mg/ day and 4–8 mg/day respectively for 6 months. Results: There was significant improvement in executive functioning in both the groups and the results were statistically significant for clozapine on TMT–B. Conclusion: The findings of current study show that both risperidone and clozapine lead to improvement in executive functioning in first episode of schizophrenia and clozapine fared better than risperidone.