Adverse drug reaction is an important agenda of the pharmacovigilance programme of India. In that contest, Toxic Epidermal Necrolysis is severe episodic mucocutaneous reaction caused as a result of ingestion of drugs like sulfonamide, Aminopenicillin, phenopthalein, oral hypoglycaemic drugs, isoniazide etc. The main objective here is to report a fatal case of Toxic Epidermal Necrolysis in a woman who was treated with 400 mg of ofloxacin for enteric fever. Although,Toxic Epidermal Necrolysis is infrequent, but it is fatal. Fluroquinolones rarely causes TEN and there is limited published information regarding ofloxacin induced TEN. So, it is concluded that this case report may creates an awareness about ofloxacin induced TEN