The present study was aimed to find the effect of amorphous hydrogel dressings with silver nano particles versus conventional dressing on wound culture and slough in patients with diabetic foot ulcers. This two year randomized controlled trial was done in the Department of Surgery, J.J.M. Medical College, Davangere. A total of 60 patients with chronic diabetic foot ulcers from September 2015 to August 2017 were enrolled. Patients were divided into two groups of 30 each as group A (using hydrogel with silver nano particles) and group B (with povidone iodine).