Background: “Menopause” term is derived from the Greek word ‘men’ means ‘month’ and ‘pauo’ means ‘to stop’ that is cessation of menstrual period. Menopause is a natural step in the process of ageing in a woman‘s life. The hormonal changes associated with menopause e.g., low plasma levels of estrogen and marked increase in follicle stimulating hormone levels exert a significant effect on metabolism of plasma lipids and lipoproteins. A number of changes that occur in the lipid profile after menopause are associated with increased cardiovascular disease risk

Objective: To compare lipid profile  status in pre and post menopausal women.

Materials and Methods: This was a cross–sectional study conducted among total 100 female subjects including 50 healthy premenopausal women as controls and 50 healthy postmenopausal women as cases. Effort was made to match the controls with cases .5 ml fasting venous samples was taken for serum measurement of lipid profile i.e. TG,HDL,LDL,VLDL and serum cholesterol and samples were analysed in semi–auto analysers.

Results: The distribution of  body weight and BMI among both of the groups has been found statistically significant hence the significant increased levels of BMI as well as body weight was  observed in postmenopausal group in comparison of  premenopausal women. (p value <0.05) and similarly lipid profile distribution  among both of the group was  also found statistically significant.

Conclusion :This study suggests that there is increase in atherogenic lipid profile in postmenopausal women as compared to premenopausal women i.e. postmenopausal women have more cardiovascular disease risk hence a timely health check up must be intensified specially among postmenopausal women.