The aim of the study was to evaluate the effect of chemotherapy with radiotherapy in dysphagia relief in patients with locally advanced carcinoma of esophagus.This is a prospective study comprised of 60 patients of various age group and were randomly divided into two equal groups. One group was treated with induction chemotherapy followed by chemoradiation while the other group was treated with radiotherapy alone. Post therapy both the groups were followed up for evaluation of dysphagia relief. During the study period the response to chemoradiation was 70 % whereas in radiotherapy alone group the response was 63.3%. However, statistically no significant difference (p>0.05) was observed between the groups in respect of dysphagia relief. The combination of chemotherapy with radiotherapy significantly improves dysphagia relief in patients with carcinoma of esophagus.