Enteric fever is characterized by sepsis & endotoxemia affecting lipid metabolism. Present study included quantitation of serum lipids in 50 patients of enteric fever at the time of admission, during follow up after 6 weeks, 3 months and 50 age, sex matched healthy control subjects. Enteric fever patients showed significantly increased levels of serum triglycerides, total cholesterol, LDL cholesterol, VLDL cholesterol, total cholesterol / HDL cholesterol ratio and decreased levels of HDL cholesterol in comparison with control subjects. Maximum alterations in above biochemical parameters were seen in enteric fever patients after 3 weeks follow up (p < 0.05). Elevated total cholesterol / HDL cholesterol ratio in typhoid patients warns about possible atherosclerotic involvement.