Liver abscess remains a diagnostic dilemma and concerning problem from clinical outcome angle. The etiological agents and risk factors of the liver abscess have seen evolving trend over the years. Salmonella Typhi a traditional agent of typhoid fever is never considered as an important proponent in liver abscess though it is being increasingly isolated from extra–intestinal sites such as liver, bones, joints, breast tissue etc. It is because of these reasons that rapid identification of the causative agent becomes crucial for obtaining successful outcomes through institution of effective management tools and any omission or delay in catching this organism may prove detrimental to the clinical course of the disease.