Aphthous ulcers are the most common type of inflammatory efflorescence of oral mucosa. Topical anesthesia is widely advocated in dental practice to reduce pain caused by different oral conditions. Hence, the clinical effectiveness of topical anesthetic agents viz. Precaine_® (8% Lidocaine + 0.8% Dibucaine) was compared with Precaine^® B (20% Benzocaine) in the pain relief of aphthous ulcers.  Both the products were used alternately in two different visits and the individual’s pain response was assessed in a total of 40 patients using VAS pain scale. Statistical comparision between the two products showed higher mean score for Precaine^® B when compared to Precaine_®. A visit wise comparision was also made using student’s t–test and Precaine^® B reported significant lower scores (P<0.05) in visit 2. Thus, its concluded that combination agents – 8% Lidocaine + 0.8% Dibucaine can be used as effectively as 20% Benzocaine for the symptomatic treatment of aphthous ulcers.