Objective: To check the outcomes of Regenerative Endodontics procedure  in immature permanent teeth with necrotic pulps using different antimicrobial agents And/Or Intracanal medicaments using different protocols.

Data sources: Internet sources of evidence were used were MEDLINE PubMed and the CENTRAL, Google Scholar, manual search using college library resources. All cross reference lists of the selected studies were screened for additional papers that could meet the eligibility criteria of the study. Articles published between 1^st January 2000 and 31^th August 2016

Results: Preliminary screening consisted total of 250 articles out of which 52 articles were selected. Only 29 papers with full– text were selected

Conclusion: Sodium hypochlorite was used in all the studies and hence thought to be the best irrigant. Triple/double antibiotic paste has shown maximum positive result. MTA was proved to be the best for coronal sealing over the blood clot.