This comparative group study was done to evaluate the efficacy and safety of topical ketoconazole with topical luliconazole during a period of 4 weeks. 100 patients of dermatophytosis were selected from the skin department & were divided into two groups, each group consist of 50 patients. The patients in Group A were administered topical ketoconazole of 2% cream, and in Group B patients, topical luliconazole of 1% cream was applied topically. Diagnosis was confirmed by microscopic potassium hydroxide (KOH) examination. Global assessment was done at the end of treatment with mycological reduction in signs and symptoms (pruritus, erythema and desquamation) of tinea infections as compared to baseline by microscopic potassium hydroxide (KOH) examination