Background: Depression is a psychiatric disorder, related to a feeling of sadness and loss of interest that affects how one feels, thinks, as well as behaves, and can lead to a variety of emotional and physical problems¹. Symptoms of depression include depressed mood, loss of interest or pleasure, diminished concentration, feelings of guilt and unworthiness, disturbed sleep, changes in appetite, thoughts of suicide, and impairment of daily functioning^2,3.

Methods: The Present study was conducted in Department of Biochemistry in association with Department of Psychiatry, Sardar Patel Medical College and attached Hospital, Bikaner. There were 50 cases and 50 controls in the age groups from 25–65years. We took fresh samples and performed required tests following standard protocol.

Results: The Mean±SD of Serum CRP (2.52±0.55 mg/dl), TG (220±26.72 mg/dl) and VLDL (44±5.34 mg/dl) Levels were significantly increased and TC (141.4±5.96 mg/dl), HDL–cholesterol (32.46±3.95 mg/dl), LDL–cholesterol (69.73±10.04 mg/dl) levels were significantly decreased in patients of depression.

Conclusion: In this study serum CRP level was raised in newly diagnosed depressive patients indicates that there may be some correlation with inflammatory mechanism in depression. Abnormal lipid profile results shows some alteration in brain chemistry or brain function cause improper function of brain leading to mental disorder. This study may help to understand the pathophysiology and metabolic derangement in lipid profile in depression.