Background: Hypothyroidism is the common disorder of endocrine system in humans. They are encountered among all ethnic groups and in almost every country around the world. Mostly occur in the regions where iodineis scarce component ofsoillike typically remote inland areas where no marine foods are eaten and in mountainous regions of the world where food is grown in iodine–poor soil.Hypothyroidism is clinical syndrome caused by deficiency of thyroid hormones that cause generalized slowing of metabolic processes.The present study aimed to find out the serum creatinine, uric acid and zinc level in hypothyroid patients in the tertiary care hospital in Bikaner, western Rajasthan, India.

Material & methods: This study was conducted at Sardar Patel Medical College and associated hospital in Bikaner, Rajasthan from June 2016 to Feb 2017. There were 40 cases and 40 controls in the age groups from 18 to 65 years. Fresh samples were taken and required tests were performed following standard protocol. Creatinine and uric acid level was estimated by semi auto analyzer and zinc level was estimated by atomic absorption spectrophotometer.

Result: Level of serum creatinine and uric acid was significantly high and serum zinc was significantly low (p–value<0.0001) in hypothyroid patients.

Conclusion: In this study the role of serum creatinine, uric acid and zinc has been explored. The high level of creatinine and uric acid was found due to reduction in renal plasma flow and glomerular filteration rate and low serum zinc was found due to impaired gastrointestinal absorption of zinc in hypothyroid subjects or change in zinc distribution due to sequestration of zinc by the liver.