Rheumatoid Arthritis is a chronic inflammatory disease. Several inflammatory biochemical markers have been associated with the disease. We evaluated the role of Ceruloplasmin and Adenosine deaminase as potential serum biomarkers in Rheumatoid Arthritis. Fifty consecutive cases of Rheumatoid Arthritis along with age and sex matched 50 controls were included in the study. Paired serum Ceruloplasmin and Adenosine deaminase were measured in all cases after diagnosis of Rheumatoid Arthritis was confirmed as well as eight weeks after the institution of Disease Modifying Antirheumatic Drug therapy. Results were analysed using Students‘t’test. Ceruloplasmin and Adenosine deaminase were found significantly raised compared to controls indicating their possible role as adjuncts in diagnosis of Rheumatoid Arthritis, however their role as potential follow up tool needs to be elucidated by further larger studies .