Waterborne diseases are linked to significant disease burden worldwide. Diarrhoeal diseases due to infectious agents such as pathogenic salmonella species are responsible for two million deaths each year. The bulk of morbidity and mortality due to pathogenic salmonella species occurs in developing countries such Nigeria due to poor sanitary and sewage facilities. This study was carried out to determine the extent of contamination of well–water by Salmonella spp and to ascertain its antimicrobial resistance profile to commonly prescribed drugs in Ganye town.A total of 98 samples from seven locations were collected and processed. 51 samples yielded Salmonella spp, which gives a total recovery rate of 52.04%. Rate of isolation was highest in Tappare (23.53%) and Tudun Wada (19.61%) but least in Ganye 1 (5.88%). Isolates were highly resistant/least sensitive to Gentamycin (78.43%/5.88%) and highly sensitive/least resistant to Ampicillin (92.15%/1.96%), Ciprofloxacin (90.2%/3.39%) and Ofloxacin (80.04%/0.00%). This study revealed heavy contamination of well–water with Salmonella. Thus, the need for the provision of portable pipe–borne water to the populace is hereby advocated.