Oxidative stress is important marker in nephrotic syndrome and its secondary disease lupus nephritis. Oxidative stress contributes to the pathophysiology of kidney injury. Membranous nephropathy is the most important cause of the nephrotic syndrome in elderly patients. Reactive oxygen species play an important role in the pathogenesis of different glomerulopathies. The purpose of this study was to examine selected markers of oxidative stress and antioxidant defense in nephrotic syndrome & lupus nephritis. Therefore, this study was carried out to investigate oxidant and antioxidant status in nephrotic syndrome and lupus nephritis patients. The blood samples were analyzed for quantitation of malondialdehyde as index of lipid peroxide, vitamin C, total antioxidant capacity, homocysteine, lipoprotein (a) & lipid profile. Significantly increased levels of serum total cholesterol, low density lipoprotein, malondialdehyde, homocysteine, lipoprotein (a) (p<0.001) and decreased levels of serum high density lipoprotein, total antioxidant capacity, total protein, albumin, & plasma vitamin C (p<0.001) were noticed in the patients with lupus nephritis as compared to nephrotic syndrome and control subjects. In conclusion the oxidative stress is enhanced in nephrotic syndrome & lupus nephritis patients due to hyperhomocysteinemia, hyperlipoproteinemia and hypoproteinemia. Lupus nephritis patients had more Oxidative stress than nephrotic syndrome patients