Dercum‘s disease also referred to as Anders‘ syndrome, Adiposis Dolorosa, or Dercum–Vitaut syndrome is one among the rarest medical conditions. It was first described in 1892 by Francis Xavier Dercum. It is more common in postmenopausal women and is characterized by painful subcutaneous lipomas or fat accumulations largely on the trunk and limbs. There is also associated asthenia, easy bruising over the affected areas and hypercholesterolemia . Dercum’s disease is believed to be transmitted in an autosomal dominant manner , however most reported cases of adiposis dolorosa are sporadic . The understanding of the pathogenesis and the mechanism of Dercum’s disease remain unknown. It is believed that fatty deposits cause nerve compression and result in weakness and pain.