Background: Subclinical Hypothyroidism is a progressive disorder that presents with diverse degrees of thyroid failure and metabolic consequences. It potentially affect metabolism which may influence renal development, kidney structure, renal plasma flow, glomerular filtration rate, and nephron transport system. This may leads to change various biochemical constituents in patients. Hemodynamic changes occur in hypothyroidism that leads to reduction in renal plasma flow and glomerular filtration rate, which also causes increase in the levels of serum urea and serum creatinine.

Objectives: To estimate serum creatinine and urea levels in healthy controls and subclinical hypothyroid patients; and to compare the results of the above two groups and correlate these values with TSH values in subclinical hypothyroidism cases.

Materials and methods: A cross–sectional study was done and included 200 individuals (100 Subclinical hypothyroid cases and 100 normal controls). Serum TT3, TT4, TSH levels were estimated by Chemiluminescent microparticle Immunoassay(CMIA) method to assess the subclinical hypothyroid cases. Serum Urea and Creatinine were estimated by colorimetric method on Semi automated chemistry analyser. Statistical analysis was done using students‘t’ test. Pearson’s correlation coefficient test was done to establish the relationships between the parameters.

Results: The serum creatinine level was significantly elevated in subclinical hypothyroidism cases in comparison to controls. Serum urea concentrations were not significantly different in the studied groups.

Conclusion: Subclinical Hypothyroid state is associated with hemodynamic changes like reduction in renal plasma flow and glomerular filtration rate, which causes increase in the levels of serum urea and creatinine.. Hence these parameters should be regularly monitored in Subclinical hypothyroid patients.