Introduction:

Postoperative nausea and vomiting(PONV) is a distressing complication after anaesthesia, which should be prevented to accelerates postoperative recovery and patient satisfaction. Therefore this study was conducted to compare the efficacy and safety of ramosetron and ondansetron in patients undergoing standard laparoscopic cholecystectomy

Methodology:

This prospective, randomized, double blinded comparative study was carried out at department of Anaesthesiology, Medanta Abdur Razzaque Ansari Memorial Weavers’ Hospital, Ranchi. Total of 168 patients undergoing laparoscopic cholecystectomy under general anaesthesia were randomized into group O and group R based on a computer generated random table to receive Ondansetron 4 mg IV and ramosetron 0.3 mg IV respectively. Patients were closely monitored for first 24 hour post–surgery for post–operative nausea and vomiting.

Results: It is concluded that, prophylactic administration of single dose of ramosetron 0.3 mg iv has better efficacy and is more potent than single dose ondansetron 4 mg iv in reducing  post–operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.