In developing countries, neonatal mortality (death in the first 28days of life per 1000 live births) due to all causes is about 34 per 1000 live births, most of these deaths occur in the first week of life. In developing countries sepsis is the commonest cause of mortality responsible for 30% to 50% of 5 million neonatal deaths every year. A Sincere effort has been put in this study to understand Clinical Manifestations among clinical sepsis and Blood Culture Positive Sepsis Patients in NICU. A Sincer effort has been put to Study of Bacterial Profile in Proven Sepsis in NICU.