Infertility is a critical component of reproductive health ^[1]. The inability to have children affects men and women across the globe. Infertility can lead to distress and depression, as well as discrimination and ostracism ^{[1, 2]}. Parental consanguinity might have deleterious effects for the reproductive health of future generations. Similarly, the trend of older parenthood is true for both men and women. Infertility is multi–factorial but it is important to understand the effect of advanced age, consanguineous marriages & chromosomal aberration on fertility.