Nephrotic syndrome often manifesting in progression of amyloid nephropathy. Secondary amyloidosis  is a well known cause of nephrotic syndrome.Therefore, this study was carried out to investigate oxidant and antioxidant status in nephrotic syndrome and amyloid nephropathy patients. The blood samples were analyzed for quantitation of malondialdehyde as index of lipid peroxide, vitamin C, total antioxidant capacity, homocysteine, lipoprotein (a) and lipid profile, total protein and albumin with copper and zinc. Significantly increased levels of serum total cholesterol, triglycerides, low density lipoprotein, malondialdehyde as index of lipid peroxide, lipoprotein (a), homocysteine (p<0.001) and decreased levels of serum total antioxidant capacity, total protein, albumin, high density lipoprotein & plasma vitamin C (p<0.001), copper and zinc were noticed in the patients with nephrotic syndrome and amyloid nephropathy as compared to control and remission subjects.