Acute febrile encephalopathy is characterized by altered mental status accompanied by or followed by short febrile illness (less than 15 days) and may be related with pyogenic meningitis, viral meningoencephalitis, tubercular meningitis, cerebral malaria and sepsis associated encephalopathy. Bacterial meningitis is represented by an acute purulent infection within the subarachnoid space results in decreased consciousness, seizures, raised intracranial pressure and stroke. Immunocompetent adult patients with viral meningitis present signs of headache, fever, and meningeal irritation coupled with an inflammatory CSF profile. Tuberculosis can attack any nervous tissue including the meninges, brain and the spinal cord. We conducted a data based study in continuation of our previous studies to elucidate the association of acute febrile encephalopathy with clinical profile of patients and geographical area where do the patients belong.