Randomised, prospective, comparative study was conducted in Government Medical College, Amritsar. 60 patients of hypertension with hyperuricaemia were assigned into two groups of 30 patients each.  Group A was treated with Losartan 50mg and group B received Amlodipine 5mg, once daily orally. BP was recorded every 2 weeks for 12 weeks and serum uric acid was monitored every 4 weeks for 12 weeks. Systolic /diastolic blood pressure decreased by14.80/10.13 mm Hg respectively in group A and by 14.20/11.53 mm Hg respectively in group B which was highly significant (p < 0.001).  Intergroup difference was non–significant.  SUA reduction with losartan (22.69%) was more as compared to amlodipine (4.45%) and difference was statistically significant (p<0.05).  Both the drugs were well tolerated in both the groups. Losartan was more efficacious in hypertensive patients with concomitant hyperuricaemia than amlodipine.