Death as such is not an uncommon phenomenon but deaths due to blood transfusions are rare. Such cases attract a lot of controversies involving competency of the doctors, medical institutions and state of health of the health system in that region. Despite advancement in diagnostic and therapeutic procedures, Infective endocardititis carries poor prognosis and high mortality. An alleged case of sudden transfusion death which on autopsy turned out to be death due to complications following dislodgement of septic emboli from Infective endocarditis over heart valves is rare. Present case proves the fact that meticulous collection of samples post transfusion reaction, history and autopsy aids in establishing the actual cause of death rather than alleged one.