Duodenojejunal flexure is located anterolateral to aorta at the level of the upper border of the second lumbar vertebra. Duodenojejunal flexure is suspended from the ligament of Treitz, which serves as surgical landmark. Duodenojejunalflexure pathologies isarareentity,thepresentingfeaturesofwhicharevagueandnon–specific. Any pathology in this area is difficult to deal surgically because of this proximity to many important vessels and viscera.Wereporttwo suchcases, adenocarcinoma of duodenojejunal flexure and SMA Syndrome both presenting as acute intestinal obstruction.