critical care settings. In CRS 1 has a multifactorial pathophysiology and presents with sudden onset decrease in urine output and raised serum BUN

and creatinine levels and also worsening of acute cardiac disease. CRS type 1 is a challenge to the treating physician because it results in increased

morbidity and mortality of the cardiac patients.

Aim: To study the clinical profile of patients with cardiorenal syndrome type 1 and their in–hospital outcome

Methods: In this cross sectional prospective study, 50 consecutive subjects suffering from acute cardiac conditions were screened for CRS I and

enrolled .They were assessed clinically, evaluated as per Performa and followed up for in hospital outcome in form of survival and hospital stay.

The primary outcome was in–hospital mortality and secondary outcome was duration of hospital stay. During the study period all patient received

standard line of management as per the clinical diagnosis.

Result: Mean age for all 50 patients with CRS 1 was 56 ± 14 years, with 56% males and 44% females. The Mean age for male patients was 53 ± 14

yr and for female patients was 61 ± 12 years. The primary diagnosis in33 (66%) patients was ACS with acute heart failure, in 10(20 %) ACS alone,

and in 7(14%) uncontrolled hypertension with acute heart failure. The commonest co–morbidity was CAD, present in 44 patients (86%) followed

by hypertension in 28 patients (56%), COPD in 19 (38%), CKD in 13 patients (26%) and diabetes in 12 (24%). Mean SBP in study population was

120±27 mm of Hg and DBP was 78±15 mm of Hg. Mean urine output in study population at first 6 hours was 65±21 ml/kg/hr which has decreased

to 49±17 ml/kg/hr after 48 hours. Mean GFR in study population at admission was 81.3±27.9 ml/min. After 48 hour GFR was reduced to

47.4±18.96 ml/min. Total 50 patients of CRS 1 were included in the study, 11 patients (22%) expired during hospital stay and 39 patients (78%)

survived. Mean age of survivors was 52±11.53 yrs that of non survivors was 73.5±8.18 years. The mean duration of hospital stay in the survivors

was 8.97+/–1.72 days. CKD as a co morbid condition was significantly associated with mortality. There were significantly higher levels of blood

urea, serum creatinine and serum potassium in patients with in–hospital mortality. Higher stage of AKI was significantly associated with in–hospital

mortality.

CONCLUSION: From the above study we conclude that the in patients of CRS 1, males were affected at early age compared to females. ACS with

heart failure is the commonest primary diagnosis leading to CRS 1. Patients with higher age, pre existing CKD and higher stage of AKI during

hospital stay are at risk of poor outcome.