The aim of study was to measure serum level of PAPP–A and troponin T in acute myocardial infarction (AMI) patients and compaire with controls. Serum level of PAPP–A were also correlated with troponin T, risk factors, BMI and time of presentation of patient to cardiac emergency. In this case control study, age and sex matched 100 diagnosed cases of acute myocardial infarction were compared with 100 healthy participants at Jawaharlal Nehru Medical College & Associated Group of Hospitals, Ajmer (Rajasthan). Mean level of  PAPP–A and Troponin T in cases ( 1.21 ± 0.41 µg/ml and 1.35 ± 0.78 µg/L respectivily ) were significantly higher (p <0.001) then healthy controls ( 0.51 ± 0.12 µg/ml and 0.23 ± 0.06 µg/L respectivily ).The level of PAPP–A was significantly higher with low troponin T in patients with unstable angina. In this study, PAPP–A level was not associated with age, sex, risk factors and time of presentation of patients.