Background:The number of diagnostic and therapeutic procedures done outside the operating room has increased dramatically in recent years. While most of these procedures themselves pose little risk to the child, the administration of sedation or analgesia may add substantial risk.

Objective: To compare the sedative effects of Dexmedetomidine in comparison to Propofol+Midazolam in children undergoing MRI.

Materials and methods :A prospective, randomized, single blinded comparative study between two anaesthetic agents in a teaching hospital. A sample size of 30 patients in each group, as calculated from the power of previous studies was taken, setting a significance level of P = 0.05, it was calculated that a group of 30 patients allowed the power of the study to be 95 %.Group “P”: Patients receiving Midazolam+Propofol combination. Group “D”: Patients receiving Dexmedetomidine alone

Results :  Propofol+Midazolam provided faster onset of sedation, recovery, and discharge times than dexmedetomidine.The time to Ramsay Sedation Scale =5 was significantly higher in Group D (Mean=12.20 minutes, SD=2.01 minutes) as compared to Group P (Mean = 6.30 min, SD =1.32  minutes), P value=0.001(P value significant if <0.05).The time to Aldrete Score 10/10 was also significantly higher in Group D(Mean = 21.10 minutes SD = 1.84 minutes) as compare to Group P (Mean = 13.73 minutes SD = 1.89 minutes),P value=0.001(P value significant if <0.05).