Aims–To evaluate the association between the serum sodium level and severity of complication in cirrhosis and its prognostic significance.

Methods:–Data of 100 patients in rohalkhand region with cirrhosis were collected prospectively

Observations and Results:– The serum sodium level were strongly associated with the severity of liver function impairment as assessed by Child–Pugh and MELD[3] score (p=<0.0001). 92(46%) belong to the group of serum sodium concentrations ≥136 meq/L. While, 68(34%) and 40(20%) patients were belong to serum sodium concentration group of ≤130 meq/L and 131–135 meq/L respectively. Patients with a serum sodium ≤130meq/L, as compared with serum sodium ≥136 meq/L had a significantly increased risk for developing complications: 17.48(95% CI=1 to 312, p=0.0086) for portal hypertension, 10.5 (95% CI=3.08 to 35.8, p=< 0.0001) for hepatic encephalopathy and15.70 (95% CI=0.86 to 287.8, p=0.0113) for hepatorenal syndrome. Patients with a serum sodium 131–135 meq/L, as compared with serum sodium ≥136 meq/L had a significantly increased risk for developing complications: 19.5 (95% CI=4.92 to 77.3, p=< 0.0001) for hepatic encephalopathy and 18.6 (95% CI=0.91 to 379.0, p=0.0249) for hepatorenal syndrome[7]. However no statistical difference and increased risk was found for ascites, portal hypertension, gastrointestinal bleeding and coagulopathy. Mortality found to be 12 %

Conclusion :– The prevalence of hyponatremia in this study wasmore than 50% and mortality was 12%. Severity of hyponatremia was associated high frequency of complications ofcirrhosis, which was a significant association between dilutional hyponatremia and hepatic encephalopathy, hepatorenalsyndrome.There was no significant association between hyponatremia andascites,Coagulopathy, varicealbleeding.