The present study aims at clinicopathological correlation of prostate carcinoma and correlation of Gleasons grade with preoperative Karnofsky Performance Status (KPS) and   preoperative total serum PSA levels.

         Total  33  histopathologically confirmed cases of  prostate carcinoma were studied and interviewed for determining KPS  preoperatively. Frequency of micturition (90%) was most common symptom.

            All cases in present study showed significantly increased PSA levels with moderate to high grade adenocarcinoma.  The most common Gleason’s grade and score encountered was 4 and 7 respectively.  

        No significant correlation found between Gleason’s score and KPS. However Age has significant inverse correlation with KPS. Thus patients presenting at relatively early age have better prognosis and treatment tolerance and are candidates for curative therapy.

  Thus PSA is reliable tumour marker. Higher grade produce more PSA. Gleason’s grading on biopsy helps in definitive diagnosis and predicting prognosis.