Background:

Laryngoscopy and endotracheal intubation (L and I) is associated with rise in blood pressure (BP), heart rate (HR), leading to adverse cardiological outcome especially in coronary artery diseases  . To compare haemodynamicresponces during L and I as well as to evaluate the preoperative status between oral clonidine (Group C) and oral gabapentine (Group G) as premedication for the patients undergoingnoncardiac surgeries having coronary artery diseases.

Materials and Methods:

In  this  prospective, double–blinded, and randomized controlled study; 100 adult patients of either sex, aged 20–70, of American Society of Anesthesiologists status II and III scheduled to undergo noncardiac surgeries, randomly allocated into groups C and G were pre treated with oral clonidine (200 µg) and gabapentin (800 mg) respectively  prior to induction. Hemodynamic parameters were noted just before induction, during L and I 1,3,5,7, and10 min after intubation. The results obtained were then analyzed with statistical unpaired “t” test and Chi–square test and compared.

Results and Analysis:

Group C attenuated HR, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) more significantly before induction, during L and I, 1, 3, and 5 min, following L and I, while comparing with group G. Again gabapentin–reduced HR, BP, (SBP, DBP, MBP) significantly more at 7 and 10 min after L and I on comparison clonidine.

Conclusion:Oral clonidine is more efficacious in reducing laryngoscopic stress response than oral gabapentin in patients with coronary artery disease posted for noncardiac surgeries.