Aim– A Two year prospective study of  clinico–etiological profile  of Ocular mycosis in western Odisha from March 2016 to February 2018.

Materials and Methods– Corneal scraping, vitreous, aqueous fluids and conjunctival swabs after the slit–lamp examination were collected under strict asepsis from suspected patients of oculomycosis.. Direct microscopy of 10% potassium hydroxide (KOH) wet mounts, gram staining, fungal and bacterial cultures were performed in the dept of microbiology

Result–. Fungal isolates were obtained in 21.42% patients with slight male preponderance and average agebeing  44 years. KOH wet mount showed  fungi in 67.85%% samples. Aspergillusspp. (52.77%), Fusarium spp. (33.33%), Candida sppin 11.11% and melanised fungi (2.77%) were common etiological agents. Mucormycosis was reported in two diabetics. Fusarium spp. was more often associated with complications. Trauma was a predisposing factor in 75% cases and occurred mainly with vegetable matter. The majority responded to the conservative management with 5% natamycin and six patients underwent therapeutic keratoplasty.

Conclusion–Ophthalmic mycosis is a major cause of visual impairment. In contrast to other studies on fungal keratitis, Aspergillusspp.Was the most commonly isolated fungal pathogen which carries the worst prognosis. This study recommends early surgical intervention to improve the outcome.