The present study was undertaken to investigate the effect of the aqueous extract of Allium sativum L. (Family: Lilliaceae), commonly known as garlic, on antidepressant in albino rats. Aqueous extract of garlic (250, 500and 1000mg/kg) was administered orally for 20 successive days to young albino rats of either sex and antidepressant– like activity was evaluated employing tail suspension test (TST) and Forced swim test(FST). The efficacy of the extract was compared with standard antidepressant drugs like imipramine. Garlic extract significantly decreased immobility time in a dose–dependent manner in both TST and FST, indicating significant antidepressant activity. The efficacy of the extract was found to be comparable to imipramine (15 mg/kg p.o.) in both TST and FST treated group. Garlic extract administered orally for 20 successive days showed significant antidepressant–like activity.