IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-4-14982 Original Research Paper Effect Of Tween 20 And Tween 40 Surfactants On 5-Fluorouracil Niosomes SHUKLA Dr. April 2018 7 4 01 02 ABSTRACT

 Niosomes (Non–ionic surfactant vesicles) have become promising alternatives to liposomes because they are more economic and chemically

stable. Hence, Niosomes of 5–Fluorouracil were prepared by using Tween 20 and Tween 40, by ether injection method (EIM). Niosomes of Tween
40, which proved to be the best formulation, showed a mean vesicle size of 5μm and entrapment efficiency of Tween 20 and Tween 40 were found to
be 46.40% and 39.20%. The cumulative % drug release of Tween 20 and Tween 40 were 86.41% and 92.84% respectively in 12 h. The tissue
distribution studies of Tween 40 formulation reveal that the drug loaded niosomes showed preferential drug targeting to liver followed by spleen
and lungs.