Introduction:

Obesity is one of the major public health problems of the world wide. Obesity leads to insulin resistance and abnormal lipid profile and these are some of the attributable risk factors of cardiovascular disease.Pancreatic β cells dysfunction caused by dyslipidemia precedes the manifestation of type 2 diabetes mellitus (T2DM) and is an independent risk factor for the development of T2DM. Moreover, few studies have compared β cell function with dyslipidemia . The aim of this study is to find out the correlation of β cell function with lipid profile and BMI in North–Indian obese adults.

Material and methods:

This was cross–sectional study conducted in total 100 obese adults of age group between 20–50 years with no obvious causes for obesity after taking informed consent. Anthropometric data, blood pressure, basic blood tests (CBC, LFT, RFT, FBS, Fasting Insulin, Lipid profile), ECG, CXR of the patients were done by standard method. Insulin resistance (HOMA–IR) and Beta cell function (BCF%) were calculated by using computer based HOMA2 calculator. All collected data were analyzed and the correlation between beta cell function with lipid profile parameters and BMI were studied.

Results:

We observed spastically significant correlation of Beta cell function with   lipid parameters (Total Cholesterol, Triglycerides, Low Density Lipoprotein, Very Low Density Lipoprotein and high Density Lipoprotein ) and BMI  in obese adults.

Conclusion:

Thecurrent study concludes that there is statistically significant positive correlation of Beta cell function with lipid profile and BMI in north–Indian obese adults..  Consequently, dyslipidemia and high BMI with impaired β cell function should be paid more attention.